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KMID : 1140220180230010018
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대한암예방학회지
2018 Volume.23 No. 1 p.18 ~ p.24
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Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice
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Yang Joon-Yeop
Zhong Xiancai
Kim Su-Jung
Kim Do-Hee
Kim Hyun-Soo
Lee Jeong-Sang
Yum Hye-Won
Lee Jee-Woo
Na Hye-Kyung
Surh Young-Joon
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Abstract
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Background: Curcumin, a yellow ingredient of turmeric (Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved.
Methods: Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0.1 or 0.25 mmol/kg body weight daily) for 7 days before and together with DSS administration (3% in tap water). Collected colon tissue was used for histologic and biochemical analyses.
Results: Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-κB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase. In contrast to curcumin, its non-electrophilic analogue, tetrahy-drocurcumin has much weaker inhibitory effects.
Conclusions: Intragastric administration of curcumin inhibited the experimentally induced murine colitis, which was associated with inhibition of pro-inflammatory signaling mediated by NF-κB and STAT3.
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KEYWORD
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Curcumin, Dextran sulfate sodium-induced colitis, NF-κB, STAT3, Tetrahydrocurcumin
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